![]() On illness days 6 to 10, she remained afebrile with minimal cough and clear breath sounds. The patient was thus identified by the Department of Health as the first confirmed COVID-19 case in the Philippines. On January 30, the result of the initial NPS/OPS sent to VIDRL reported detection of 2019-nCoV (subsequently termed SARS-CoV-2) viral RNA by real-time PCR. On January 29, further NPS/ORS specimens were collected and sent to the RITM. The NPS/OPS specimen was then sent by RITM to the Victorian Infectious Disease Reference Laboratory (VIDRL) in Melbourne, Australia, for COVID-19 testing. A 10-day course of oseltamivir 75 mg BID was given on the basis of the influenza result. These assays reported detection of Influenza B viral RNA, human coronavirus 229E viral RNA, Staphylococcus aureus DNA and Klebsiella pneumoniae DNA. On January 27, the results were released of a commercially available respiratory pathogen multiplex real-time PCR for detection of pathogen genes on the NPS/OPS samples (FTD Respiratory pathogens 33, Fast Track Diagnostics) at the RITM Molecular Biology Laboratory. Patient 1 did not fit the PUI criteria due to absence of fever, but was also isolated because of possible exposure. On admission, patient 2 was classified as a COVID-19 person under investigation (PUI) based on his travel history and fever and was transferred to a designated isolation area with negative pressure rooms. In Manila, patient 2 was denied entry to a hotel because he was febrile and both patients were transferred to San Lazaro Hospital (SLH), the national referral hospital for infectious diseases. Due to persistence of symptoms of patient 2, they travelled to Manila on January 25. Patient 1, a 39-year-old female, developed cough and sore throat on January 21. During January 20 to 25, they travelled from Wuhan via Hong Kong to several locations in the Philippines (Fig. It was reported that he was in contact with someone that was unwell in Wuhan, but not that he had visited the seafood market. Patient 2, a 44-year-old male, reported fever on January 18, 2020, whilst the couple were residing in Wuhan, China. They had no known comorbidities and reported no history of smoking. Continued vigilance is required to identify new cases.īoth patients were Chinese nationals on vacation in the Philippines travelling as a couple. As of March 1, there have been three confirmed COVID-19 cases in the Philippines. ![]() Despite both patients being young adults with no significant past medical history, they had very different clinical courses, illustrating how COVID-19 can present with a wide spectrum of disease. This case report highlights several important clinical and public health issues. He was thus confirmed as the first COVID-19 death outside of China. On February 1, the patient’s condition deteriorated, and following a cardiac arrest, it was not possible to revive him. On January 31, SARS-CoV-2 viral RNA was reported to be detected by PCR on the initial swabs, and he was identified as the 2nd confirmed COVID-19 infection in the Philippines. He was treated for community-acquired pneumonia with intravenous antibiotics, but his condition deteriorated and he required intubation. Influenza B and Streptococcus pneumoniae were detected by PCR on initial NPS/OPS swabs. Patient 2, a 44-year-old male, had symptoms of fever, cough, and chills. Her symptoms resolved, and she was discharged. On January 30, SARS-CoV-2 viral RNA was reported to be detected by PCR on the initial swabs and she was identified as the first confirmed COVID-19 case in the Philippines. Influenza B, human coronavirus 229E, Staphylococcus aureus and Klebsiella pneumoniae were detected by PCR on initial nasopharyngeal/oropharyngeal (NPS/OPS) swabs. Patient 1, a 39-year-old female, had symptoms of cough and sore throat and was admitted to San Lazaro Hospital in Manila on January 25. Case presentationīoth patients were previously healthy Chinese nationals on vacation in the Philippines travelling as a couple during January 2020. We describe the clinical and epidemiological aspects of the first two confirmed COVID-19 cases in the Philippines, both admitted to the national infectious disease referral hospital in Manila. ![]() The first suspected case in the Philippines was investigated on January 22, 2020, and 633 suspected cases were reported as of March 1. The novel coronavirus (COVID-19) is responsible for more fatalities than the SARS coronavirus, despite being in the initial stage of a global pandemic.
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